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Shinkar, D. M.
- Liquisolid Technology: A Review
Abstract Views :208 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjineri, Nashik, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjineri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 3 (2016), Pagination: 161-166Abstract
Liquisolid system is a novel concept of drug delivery via oral route. Solubility is the phenomenon of dissolution of solid in liquid phase and is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Poorly water soluble compound’s oral administration often require high doses in order to reach therapeutic plasma concentrations because insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability and one of the most challenging aspects of drug development. Design of this technique was according to new mathematical model proposed by Spireas et al. The drug is dissolved or dispersed in suitable non-volatile solvent and this liquid medication is converted to free flow powder by using carrier and coating material. To this suitable excipients were added and tabletting by direct compression. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties. Large scale production of fabricated drug on commercial level. Succesful liquisolid tablet is a determination of optimal flowable liquid retention.Keywords
Liquisolid System, Dissolution of Solid.- Revolutionized Topico-Systemic Era:Transdermal Drug Delivery System
Abstract Views :205 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 6, No 2 (2015), Pagination: 66-76Abstract
At present oral route is one of the most widely accepted route of drug administration, but owing to its drawbacks of low bioavailability as a result of hepatic first pass metabolism a new system was introduced for controlled delivery of drug. Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, decreased side effects, easy use and better patient compliance. Transdermal drug delivery system (TDDS) involves drug transport to viable epidermal and/or dermal tissue of the skin for local therapeutic effect while a major fraction of drug is transported into systemic blood circulation. Transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. An advantage over other routes is that the patch provides a controlled release of medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The present review describes various types of Transdermal patches, permeation strategies, their methods of preparation, evaluation techniques and their future trends.Keywords
Transdermal Drug Delivery System, Transdermal Patch.- Kleptomania: An Overview
Abstract Views :199 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra
2 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra
2 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 2 (2016), Pagination: 127-130Abstract
Kleptomania is an impulse control disorder characterised by emotional or behavioural self-control. Patient fails to resist impulses to steal items although not required for personal use or for monetary value. The symptoms include repeated theft of objects not needed, increasing tension before committing theft and relief after theft. The present article gives account on causes of disorder, its symptoms, history, different approaches to treat disorder and various hormonal imbalance associated with it. Various antidepressant drugs have been in use for the treatment along with psychotherapy.Keywords
Kleptomania, Impulse Control Disorder, Selective Serotonin Reuptake Inhibitors.- Microsponges
Abstract Views :226 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 2 (2016), Pagination: 77-84Abstract
The drug delivery technology landscape has become highly competitive and rapidly evolving. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Peptides, proteins and DNA-based therapeutics cannot be effectively delivered by conventional means. To control the delivery rate of active agents to a predetermined site in human body has been one of the biggest challenges faced by drug industry. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is an area of research that is successively done by the Microsponge delivery system. This review covers the advantages of Microsponges, their formulation and applications in pharmaceutical field.Keywords
Microsponge, Controlled Release, Topical Drug Delivery, Oral Drug Delivery, Liquid-Liquid Suspension Polymerization.- Superdisintegrants:A Review
Abstract Views :178 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 2 (2016), Pagination: 107-112Abstract
Disintegrants are the substances that causes the rapid disintegration of the capsules or tablets into smaller particles that dissolves more rapidly than in the absence of the disintegrants. On the other hand superdisintegrants, are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate. Superdisintegrants categories such as synthetic, semi-synthetic, natural and coprocessed blends etc. They are used in mouth dissolving tablet as well as conventional tablet to overcome the limitations of this dosage form. Superdisintegrants are generally used at a low conc. in the solid dosage form. The present review comprises the various kinds of Superdisintegrants like natural and synthetic which are being used in the formulation.Keywords
Superdisintegrants, Disintegrants, Fast Release, Swelling, Wetting.- Review Article:Solubility Enhancement by Solid Dispersion
Abstract Views :260 |
PDF Views:6
Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN